Important vitamin B12 Drug Potential Interaction
Metformin© is a drug used to treat diabetes.
Metformin may interfere with calcium metabolism. This may indirectly reduce vitamin B12 absorption because vitamin B12 absorption requires calcium. Surveys suggest that from 10% to 30% of patients taking Metformin have evidence of reduced vitamin B12 absorption.
In a study involving 21 subjects with type 2 diabetes, researchers found that 17 who were prescribed Metformin experienced a decrease in vitamin B12 absorption. Researchers also found that using calcium carbonate supplements (1,200 mg/day) helped limit the effect of Metformin on vitamin B12 absorption in these individuals.
Although these medications may interact with the absorption of vitamin B12, they are necessary to take for certain conditions. It is important to consult with a physician and registered dietitian to discuss the best way to maintain vitamin B12 status when taking these medications.
The Above Information Found At Office of Dietary Supplements • National Institutes of Health
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